SessionBayesian modeling of chronic & infectious diseases: Reverend Bayes going anti-viral
co-Organizers:Dani Gamerman, UFMG, Belo Horizonte, Brazil & Maia Lesosky, Cape Town, South Africa
Invited Speakers:Paula Moraga-Serrano, Bath, UK – Bayesian Geospatial Models for Tropical Disease Mapping
Jony Arrais Pinto Jr, Rio de Janeiro, Brazil – Point pattern analysis of cerebrovascular deaths in Rio de Janeiro with spatially varying covariate effects
Alexandra Schmidt, Montreal (McGill), Canada – A Poisson-multinomial spatial model for the number of cases of vector-borne diseases in Rio de Janeiro, Brazil
SessionTackling the challenges of imperfections in longitudinal and survival data: missingness, measurement error and irregular sampling
co-Organizers:Laurence Freedman, Jerusalem, Israel & Ruth Keogh, London (LSHTM), UK
Invited Speakers:Eleni-Rosalina Andrinopoulou, Rotterdam (Erasmus MC), the Netherlands – Challenges and opportunities of combined analysis of multiple outcomes in longitudinal studies
Havi Murad, Gertner Institute, Tel-Hashomer, Israel – Missing time-dependent covariate values for the Cox model – multiple imputation versus joint models approach
Shaun Seaman, Cambridge (MRC Biostatistics Unit), UK – Structural nested cumulative survival time models to adjust for time-dependent confounding
SessionCan Ying dance with Yang?: Combining evidence from RCT’s and Pharmaco-epidemiology population-based studies of drug effects
Organizer:Jessica Franklin, Harvard, US
Invited Speakers:Sara Lodi, Boston (BU), US – A three-step approach to compare randomized trials and observational studies
Jonathan Sterne, Bristol, UK – How risk of bias assessments can inform comparisons between RCTs and observational studies
Shirley Wang, Boston (Harvard), US – Unambiguously reported and replicable real-world evidence to support decision-making
SessionNew Frontiers: Big Data & Functional Data Analysis
co-Organizers:Yingying Fan, Los Angeles (USC), US
Invited Speakers:James Ramsay, Ottawa, Canada – Statistics on curved manifolds: The next frontier
Timothy Cannings, Edinburg, UK – Classification with imperfect training labels
Yingying Fan, Los Angeles (USC), US – An empirical Bayes shrinkage method for functional data
SessionCausal Inference vs. Unmeasured Confounding: Let’s face the Dragon
Organizer:Eric Tchetgen Tchetgen, Philladelphia, US
Invited Speakers:Vanessa Didelez, Leibniz Institute, Bremen, Germany – On the (In)Validity of Multiple Instruments for Mendelian Randomisation Studies
Torben Martinussen, Copenhagen, Denmark – Competing risk data and unmeasured confounding
Qingyuan Zhao, Cambridge, UK – Using sparsity to overcome unmeasured confounding
SessionWhen non-inferiority trials are superior?
co-Organizers:Lisa Hampson, Basel (Novartis), Switzerland & Toshiro Tango, Tokyo, Japan
Invited Speakers:Eisuke Hida, Osaka, Japan – Can we evaluate assay sensitivity in a non-inferiority trial?
Mimi Kim, New York (Albert Einstein College), US – Subgroup analyses in non-inferiority trials
Andrew Copas, London (MRC), UK – Non-inferiority trials to directly inform treatment recommendations
SessionCan Cox model survive in the 21st century survival analysis?
Organizer:Maja Pohar Perme, Ljubljana, Slovenia
Invited Speakers:Per Kragh Andersen, Copenhagen, Denmark – 50 years with the Cox model – 80 more to come?
Richard J. Cook, Waterloo, Canada – Challenges in causal inference with survival and life history processes
Bianca de Stavola, Un. College London, UK – The Cox model in a world of target trial emulations
SessionNew developments in Longitudinal data analysis
Organizer:Andrzej Galecki, Michigan, US
Invited Speakers:Helene Jacqmin-Gadda, Bordeaux, France – Challenges in longitudinal analysis of pre-dementia cognitive decline
Tomasz Burzykowski, Hasselt, Belgium – Design of longitudinal trials
Jeremy Taylor, U Michigan, Ann Arbor, US – Evaluation of predictive model performance of an existing model in the presence of missing data
SessionProgress in providing analytic guidance for observational studies: the STRATOS initiative
co-Organizers:Laurence Freedman, Jerusalem, Israel & Willi Sauerbrei, Freiburg, Germany
Invited Speakers:Saskia Le Cessie, Leiden University, the Netherlands – Bridging the gap between causal inference and survival analysis: a censored edition
Jörg Rahnenführer, Technische Universität Dortmund, Germany – Statistical and machine learning techniques: Which help in patient care and medical research?
Georg Heinze, Vienna, Austria & Marianne Huebner, Michigan State, US – Regression without regrets: data screening is needed before modeling
SessionIndividualized Risk Prediction & Omics
Organizer:Krista Fischer, Tartu, Estonia
Invited Speakers:Kristel Van Steen, Liège, Belgium – Precision Medicine at the Interface of Translational Science & Systems Medicine
Zoltán Kutalik, Lausanne, Switzerland – Causes and health consequences of altered transcriptome profiles
Mark van de Wiel, Free Un., Amsterdam, the Netherlands – Learning from a lot: Empirical Bayes for high-dimensional model-based prediction
SessionBiostatistical inference in practice: moving beyond false dichotomies
co-Organizers:John Carlin, Melbourne, Australia & Jonathan Sterne, Bristol, UK
Invited Speakers:Laure Wynants, Maastricht, Belgium – Dichotomania and other challenges: a perspective on principles and responsibilies
Colin Begg, New York, US – Reflections on the strengths and weaknesses of significance testing
John Carlin, Melbourne, Australia – Beyond dichotomous thinking in the analysis and reporting of clinical trials: why, how and who’s responsible?
SessionEfficient Designs & cutting-edge analyses
co-Organizers:Mitchell H. Gail, NIH/NCI, US & Sven Ove Samuelsen, Oslo, Norway
Invited Speakers:Sven Ove Samuelsen, Oslo, Norway – Use of auxiliary data for efficient analysis of two-phase survival studies
Pamela Shaw, Philadelphia, US – Methods to address correlated covariate and time-to-event error in electronic health records
Ruth Keogh, London (LSHTM), UK – Using negative controls to estimate causal effects of treatment in an entirely treated cohort
SessionStatistical challenges in Covid-19 research
Organizer:Krista Fischer, Tartu, Estonia
Invited Speakers:Els Goetghebeur, Ghent University, Belgium – Emulating trials with observational data and effect of hydroxychloroquine in hospitalized COVID-19 patients
Christopher Jackson, University of Cambridge, UK – COVID-19: Estimating the severity of the epidemic from hospitalised cohorts in the UK
Tom Britton, Stockholm University, Sweden – Basic reproduction numbers, effective reproduction numbers and herd immunity